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Naxdom 500MG Tablet


Naxdom 500 Tablet is an analgesic medication primarily used to treat migraine headaches. It combines Naproxen and Domperidone to relieve pain and prevent nausea and vomiting. It’s crucial to take it as prescribed and inform your doctor about any allergies or medical conditions. Common side effects include dry mouth, abdominal pain, and drowsiness. Pregnant or breastfeeding women should consult their doctors before using it. It works by blocking pain-inducing substances and can be taken with or without food. Dosage and duration vary based on individual needs, and regular monitoring is important, especially for older adults or those with certain medical conditions.

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Sun Pharmaceutical Industries Ltd


Naproxen (500mg) + Domperidone (10mg)


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SKU: PRO79 Category: Tag: Product ID: 10297



Naxdom 500mg Tablet is a medication belonging to the group of analgesics primarily used for treating migraine headaches. It can also alleviate pain associated with conditions like rheumatoid arthritis, gout, and dysmenorrhea (menstrual pain). The tablet combines two active ingredients: Naproxen and Domperidone. Naproxen works by inhibiting the cyclo-oxygenase (COX) enzyme, which produces pain and swelling-inducing substances called prostaglandins. Domperidone, on the other hand, acts as an antiemetic, preventing nausea and vomiting by blocking certain receptors in the brain.

It’s essential to take Naxdom 500 tablets exactly as prescribed by your doctor and for the duration recommended based on your medical condition. Common side effects may include dry mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems, and headache. Inform your doctor if you experience any discomfort.

Before starting Naxdom 500 Tablet, inform your doctor about any allergies or hypersensitivity reactions you may have to medicines or food. If you are pregnant, breastfeeding, or have a history of heart rhythm problems, ulcers due to painkillers, or other medical conditions, discuss these with your doctor before taking this medication. Patients above 65 years of age and those with pre-existing cardiac diseases, gastrointestinal bleeding, respiratory diseases, liver or kidney diseases, or bleeding disorders should use the Naxdom 500 Tablet only under medical supervision.

The medication works by blocking the release of certain chemical messengers that cause pain, inflammation, fever, nausea, and vomiting associated with migraines. It may be prescribed alone or in combination with another medicine and can be taken with or without food. The dosage and duration of treatment will vary based on individual circumstances. Common side effects like flu-like symptoms, indigestion, and dry mouth may occur, but if they persist or worsen, consult your doctor. Inform your doctor about any other illnesses or medications you are taking, and use caution if you have alcoholism or liver or kidney disease. Pregnant and breastfeeding women should consult their doctors before using this medication.


Naxdom 500 Tablet, available in a strip of 10 tablets, serves multiple purposes in managing pain, inflammation, and discomfort associated with various forms of arthritis and other ailments. Additionally, it functions as a preventive treatment for migraines and headaches, which manifest with intense head pain, nausea, vomiting, and sensitivity to light and sound.


Common Side Effects:

  • Abdominal pain
  • Constipation
  • Indigestion
  • Flatulence
  • Dry mouth
  • Glossitis (inflammation of the tongue)
  • Diarrhoea
  • Drowsiness
  • Dizziness
  • Headache
  • Vision problems
  • Hearing problems

Uncommon Side Effects:

  • Decreased sexual drive in men
  • Feeling anxious, tired, and weak
  • Headache
  • Diarrhoea
  • Itchy skin
  • Pain or tenderness in breasts

Rare Side Effects (Seek Immediate Medical Attention):

  • Swelling of the hands, feet, ankles, face, lips, or throat leading to difficulty in swallowing or breathing
  • Itchy, lumpy rash (hives) or nettle rash (urticaria)
  • Uncontrolled movements like unusual movements of the tongue, irregular eye movements, and abnormal posture such as a twisted neck, muscle stiffness, and trembling
  • Very fast or unusual heartbeat
  • Seizures or fits



Rest and relax as much as possible. Avoid strenuous activities. Applying a pain-relief balm to your forehead may help alleviate the discomfort.


Stay hydrated by drinking plenty of fluids like water or fruit juice. Avoid taking any medication without consulting your doctor.


Ensure you get enough sleep and avoid rigorous activities. Maintain a consistent sleep schedule. If the drowsiness persists, consult your doctor.


Pregnancy: NAXDOM 500 TABLET is not advised for use during the first six months of pregnancy and is strictly prohibited during the last three months. Always consult your doctor before taking it.

Breastfeeding: NAXDOM 500 TABLET is not recommended for breastfeeding women. Seek medical advice before use.

Driving and Using Machines: Avoid driving or operating machinery if you experience drowsiness, dizziness, fatigue, or blurred vision after taking the NAXDOM 500 TABLET.

Kidney: NAXDOM 500 TABLET is not suitable for patients with severe kidney disease. Consult your doctor prior to use.

Liver: Patients with severe liver disease should not use NAXDOM 500 TABLET. Always consult your doctor before taking it.

Allergy: If you have a dopamine or naproxen allergy, avoid using NAXDOM 500 TABLET.

Lungs: Use NAXDOM 500 TABLET cautiously if you have lung conditions such as asthma, other respiratory issues, or nasal polyps. Could you consult your doctor before taking it?

Heart Disease: NAXDOM 500 TABLET is not recommended for patients with severe heart conditions like heart failure or prolonged QT interval. Use with caution if you have a history of stroke or high blood pressure. Consult your doctor before use.

Other Conditions: NAXDOM 500 TABLET is not suitable for individuals who:

  • Have stomach or duodenal ulcers
  • Have gastrointestinal bleeding
  • Have an intestinal blockage or tear
  • Have a pituitary gland tumour

Before using NAXDOM 500 TABLET, inform your doctor if you:

  • possess a medical history of gastrointestinal or bowel issues (such as Crohn’s disease or ulcerative colitis)
  • Have diabetes
  • Smoke
  • possess connective tissue disorders such as systemic lupus erythematosus.
  • Have a blood clotting disorder.

Use in Pediatrics: NAXDOM 500 TABLET is not recommended for children under 5 years old. Consult your doctor before use.

Use in Geriatrics: Elderly patients (over 60 years of age) should use NAXDOM 500 TABLET with caution. Consult your doctor for guidance.


  • Take Naxdom Tablet according to your doctor’s instructions regarding dose and duration.
  • Swallow the tablet whole with water; do not chew, crush, or break it.
  • It can be taken with or without food, but it’s recommended to take it at a fixed time.
  • Follow the prescribed dose and schedule without exceeding it.
  • Your doctor will determine the correct dose and duration based on factors such as age, body weight, and medical condition.


  • The ingredients of the Naxdom 500 Tablet are Domperidone and Naproxen.
  • Naproxen, a non-steroidal anti-inflammatory drug (NSAID), blocks the release of chemical messengers causing migraine pain by reducing inflammation.
  • Domperidone, a prokinetic, acts on the brain region, controlling migraine-related vomiting and increasing stomach and intestinal movement to aid digestion.
  • Inflammatory chemicals released in the body cause pain and swelling, restricting movement and potentially damaging joints.
  • Naproxen inhibits these inflammatory chemicals, gradually alleviating related symptoms.
  • Domperidone helps control nausea and vomiting, preventing food backup in the oesophagus caused by Naproxen and other painkillers during migraine attacks.
  • Naxdom 500 Tablet effectively manages migraine by blocking brain and stomach centres, regulating nausea and vomiting while also promoting stomach contractions and movement.
  • It interrupts pain pathways and reduces the release of inflammatory substances like prostaglandins, thereby reducing pain and inflammation.


  • Taking Naxdom 500 tablet with certain medications like Amiodarone, Haloperidol, Escitalopram, Erythromycin, Ketoconazole, Lumefantrine, Cisapride, Mizolastine, and Vandetanib may lead to abnormal heart rhythm.
  • Avoid concurrent use of Naxdom 500 with Diltiazem and Verapamil, medications used for heart problems.
  • Naxdom 500 can reduce the effectiveness of Atenolol and water pills like Furosemide used for high blood pressure; hence, their simultaneous use is not recommended.
  • Maintain a gap of at least 10-12 days between Naxdom 500 and mifepristone to prevent a decrease in the latter’s effectiveness.
  • Combining Naxdom 500 with immunosuppressive drugs such as Cyclosporine and Tacrolimus may increase the risk of kidney damage.
  • Concurrent use of steroids, painkillers, and blood thinners like Warfarin and Bisphosphonates can raise the risk of stomach ulcers and bleeding.
  • Taking Naxdom 500 with antibiotics like Ciprofloxacin and Ofloxacin may lead to fits and convulsions.
  • Blood-related side effects may increase when Naxdom 500 is taken with Zidovudine used for HIV treatment.
  • Take Naxdom 500 tablets at least 1 hour before or 4 to 6 hours after Cholestyramine, a cholesterol medication.
  • Exercise caution when using other medicines like Phenytoin, Lithium, Methotrexate, Digoxin, Probenecid, Gliclazide, and Sulfamethoxazole with Naxdom 500.
  • Discuss with your doctor any other medications, herbal preparations, or supplements you are currently taking to avoid potential drug interactions.


Drug Warnings:

  • Inform your doctor if you’re using anticoagulants (e.g., warfarin), other NSAIDs (e.g., ibuprofen), corticosteroids (e.g., prednisolone), or antidepressants (e.g., citalopram).
  • Prolonged use of NSAIDs like Naproxen may heighten the risk of heart attack, stroke, and stomach ulcers, particularly in individuals with a history of ulcers, bleeding disorders, advanced age, alcoholism, or multiple diseases. Smoking and a family history of heart failure, stroke, or hypertension can also increase the risk of heart attack.
  • Seek immediate medical assistance if you experience chest pain, shortness of breath, blood in stool, dark stools, heartburn, or other unusual symptoms.

Drug Interactions:

  • Naxdom 500 Tablet may interact with other medications like NSAIDs, anticoagulants, corticosteroids, antihypertensive drugs, antibiotics, lipid-lowering drugs, and antidepressants.

Drug-Food Interactions:

  • No known interactions.

Drug-Disease Interactions:

  • Patients with peptic ulcers, inflammatory bowel disease, liver diseases, kidney diseases, heart problems, or respiratory diseases should use Naxdom 500 Tablet only under medical supervision.

Habit Forming:


Diet & Lifestyle Advice:

  • Stay hydrated to prevent gastrointestinal issues.
  • Avoid triggers that can worsen migraine headaches.
  • Ensure adequate rest.
  • Think about complementary therapies such as massage, acupuncture, and physical therapy.
  • Practice stress-reducing activities such as meditation, reading, or listening to soothing music.
  • Avoid smoking, alcohol, loud music, noisy places, extreme temperatures, and bright lights.
  • Limit consumption of chocolates, cheese, and processed foods.
  • Maintain regular meal times and sufficient sleep to help prevent migraine attacks.

Special Advice:

  • Long-term use of Naxdom 500 Tablet may require monitoring of liver and kidney function by your doctor.


  • Naxdom 500 tablet relieves pain, swelling, and discomfort associated with arthritis and other conditions, as well as treats and prevents migraine headaches.
  • Always take Naxdom 500 tablets with meals to prevent stomach upset, and follow your doctor’s prescribed dosage.
  • Inform your doctor if you’re pregnant, planning to conceive, breastfeeding, or have any medical conditions or are taking other medications.
  • Be cautious, as Naxdom 500 tablets may cause dizziness, depression, sleepiness, fatigue, or affect vision, potentially impairing your ability to drive safely, especially if you have kidney disease or a history of alcoholism.
  • Long-term use of Naxdom 500 can harm the liver and kidneys; discuss with your doctor if you’re pregnant, planning to conceive, or breastfeeding.
  • If prescribed for migraine prevention, do not use it to treat acute migraine attacks.
  • Tips to help avoid migraine attacks include maintaining regular meal times, avoiding bright lights, extreme temperatures, loud music, noisy places, chocolates, cheese, processed food, alcohol, and smoking.
  • Be cautious of its potential to cause sleepiness; refrain from driving or engaging in tasks requiring mental focus until you understand how Naxdom 500 affects you.
  • Avoid alcohol consumption as it may trigger or worsen headaches.
  • Take Naxdom 500 daily as prescribed, even if you’re symptom-free.


  • Store Naxdom 500 mg tablets below 25°C.
  • Protect them from moisture, sunlight, and heat.
  • Keep children and pets away from the drug. If you forget to take a dose, take it as soon as you recall. 
  • Dispose of expired tablets responsibly.
  • Do not flush them down the toilet or throw them in household waste or drains.


  • Overdosing on Naxdom 500MG Tablet can lead to symptoms like nausea, vomiting, stomach pain, diarrhoea, dizziness, sleepiness, excitement, irritation, unconsciousness, fits, and abnormal body movements. If you notice any of these signs or suspect you’ve taken too much, promptly contact your doctor or go to the nearest hospital for assistance.
  • In the event of a missed dose, remember that skipping doses may affect the medication’s effectiveness. Take the missed dose as soon as you remember it if you forget to take it. However, if it’s nearly time for the next scheduled dose, it’s best to skip the missed one altogether. Do not take two doses to make up for the one you missed.


Q: What is the Naxdom 500 Tablet used for?

– Naxdom 500 Tablet is a combination medication used to alleviate symptoms of migraine headaches, as well as pain associated with conditions like rheumatoid arthritis, gout, and dysmenorrhea (menstrual pain).

Q: How does the Naxdom 500 Tablet work?

– Naproxen, one of the active ingredients, inhibits the cyclo-oxygenase (COX) enzyme, which reduces the production of chemical compounds like prostaglandins responsible for pain and swelling. Domperidone, the other component, acts as an antiemetic by blocking certain receptors in the brain associated with vomiting.

Q: Can the Naxdom 500 Tablet permanently cure migraine?

– Naxdom 500 Tablet does not offer a permanent cure for migraine. It helps manage symptoms such as pain, nausea, weakness, and sensitivity to sound and light.

Q: Can the Naxdom 500 Tablet be taken long-term?

– Using Naxdom 500 Tablet for prolonged or frequent periods can potentially lead to liver or kidney issues. Therefore, it should only be used for the duration prescribed by a healthcare professional.

Q: Does the Naxdom 500 Tablet cause heart problems?

– Yes, Naxdom 500 Tablet may increase the risk of heart problems such as heart attack and stroke, particularly with high doses or prolonged use. Individuals with existing heart conditions or a history thereof should consult a doctor before using this medication.

Q: How can I deal with dry mouth caused by Naxdom 500 Tablet usage?

– Dry mouth, a possible side effect, can be managed by chewing sugar-free gum or sucking on sugar-free sweets.

Q: Does the Naxdom 500 Tablet help with migraines?

– While Naxdom 500 Tablet assists in managing migraine symptoms such as nausea, weakness, and sensitivity to sound and light, it does not offer a permanent solution. Consultation with a healthcare provider is advisable for personalized treatment.

Q: Is Naxdom 500 Tablet safe for use by pregnant and breastfeeding women?

– Naxdom 500 Tablet is generally not recommended for pregnant women during the first six months of pregnancy. It should be avoided during the final trimester. Breastfeeding women are also advised against using this medication due to potential transfer through breast milk. Consulting with a healthcare professional is essential in such cases.

Q: Does the Naxdom 500 Tablet make you feel sleepy?

– Yes, Naxdom 500 Tablet may induce sleepiness, dizziness, fatigue, or blurred vision. It is advisable to refrain from driving or operating machinery if experiencing any of these side effects.

Q: Can Naxdom 500 Tablets be taken during pregnancy?

– The use of Naxdom 500 Tablet is generally discouraged during pregnancy, especially in the first six months and the last trimester. For individualized advice, speaking with a healthcare professional is essential.

Q: Does the Naxdom 500 Tablet affect the kidneys?

– Prolonged or frequent use of Naxdom 500 Tablet can impact kidney function, as it inhibits the production of prostaglandins, which play a role in kidney health. Patients with kidney issues should exercise caution, and excessive use should be avoided.

Q: Can the Naxdom 500 Tablet cause constipation?

– Constipation is a potential side effect of Naxdom 500 Tablet, although not everyone experiences it. If constipation persists, seeking medical advice is recommended.

Q: How long does Naxdom take to work?

– Naxdom typically starts working within an hour of ingestion, with full effects noticeable within 2-3 days. Consistent adherence to the prescribed dosage regimen enhances its efficacy.

Q: What adverse effects does the Naxdom 500 Tablet have?

– Common side effects may include confusion, ringing in the ears, dizziness, tiredness, rashes, and visual disturbances. However, these symptoms are usually mild and transient.

Q: How should the Naxdom 500 Tablet be taken?

– Naxdom 500 tablets should be taken exactly as prescribed by a healthcare provider, swallowed whole with water, and not broken, cut, or chewed. Adherence to prescribed dosages and timings is essential for optimal results.

Q: Is the Naxdom 500 Tablet good for migraine?

– Naxdom 500 Tablet can be beneficial for managing migraine headaches, including associated symptoms like nausea and sensitivity to light and sound. It should only be used under medical supervision and direction.

Q: Does Naxdom make you sleepy?

– Some individuals may experience sleepiness or drowsiness with the use of the Naxdom 500 Tablet. It is advisable to avoid activities requiring mental alertness if experiencing such effects.

Q: How can I Buy or order Naxdom 500 Tablet from Aum Pharmacy?

– To buy or order Naxdom 500 Tablet from Aum Pharmacy, follow these simple steps:

  • Search for the product: Visit Aum Pharmacy’s website and search for Naxdom 500 Tablet.
  • Add to cart: Once you find the product, add it to your cart.
  • Proceed to checkout: Review your cart and proceed to checkout.
  • Prescription required: Ensure you have a valid prescription, as it may be required for purchase.
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